human MYC shRNA silencing AAV

Cat. No: shAAV-230018

Availability: 4-5 weeks

Name: AAV-h-MYC-shRNA

This is an AAV expressing shRNA for silencing of Human MYC.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MYC
Gene Name: v-myc avian myelocytomatosis viral oncogene homolog
Gene ID: 4609
Gene Synonyms: bHLHe39; c-Myc; MRTL; MYCC
ORF Size: 1365 bp
RefSeq#: NM_002467
Gene Description: MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
UniGene ID: Hs.
HGNC ID: HGNC:7553