human UGT1A7 shRNA silencing AAV

Cat. No: shAAV-229679

Availability: 4-5 weeks

Name: AAV-h-UGT1A7-shRNA

This is an AAV expressing shRNA for silencing of Human UGT1A7.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: UGT1A7
Gene Name: UDP glucuronosyltransferase family 1 member A7
Gene ID: 54577
Gene Synonyms: UDPGT; UDPGT 1-7; UGT-1G; UGT1-07; UGT1.7; UGT1G
ORF Size: 1590 bp
RefSeq#: NM_019077
Gene Description: UGT1A7 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. UGT1A7 is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols.
UniGene ID: Hs.
HGNC ID: HGNC:12539