human XRCC5 shRNA silencing AAV

Cat. No: shAAV-227927

Availability: 4-5 weeks

Name: AAV-h-XRCC5-shRNA

This is an AAV expressing shRNA for silencing of Human XRCC5.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: XRCC5
Gene Name: X-ray repair cross complementing 5
Gene ID: 7520
Gene Synonyms: KARP-1; KARP1; KU80; Ku86; KUB2; NFIV
ORF Size: 2199 bp
RefSeq#: NM_021141
Gene Description: XRCC5 is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
UniGene ID: Hs.388739
HGNC ID: HGNC:12833