human XRCC1 shRNA silencing AAV

Cat. No: shAAV-227923

Availability: 4-5 weeks

Name: AAV-h-XRCC1-shRNA

This is an AAV expressing shRNA for silencing of Human XRCC1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: XRCC1
Gene Name: X-ray repair cross complementing 1
Gene ID: 7515
Gene Synonyms: RCC
ORF Size: 1902 bp
RefSeq#: NM_006297
Gene Description: XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
UniGene ID: Hs.98493
HGNC ID: HGNC:12828