human VPS35 shRNA silencing AAV

Cat. No: shAAV-227529

Availability: 4-5 weeks

Name: AAV-h-VPS35-shRNA

This is an AAV expressing shRNA for silencing of Human VPS35.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: VPS35
Gene Name: VPS35, retromer complex component
Gene ID: 55737
Gene Synonyms: MEM3; PARK17
ORF Size: 2391 bp
RefSeq#: NM_018206
Gene Description: VPS35 belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.
UniGene ID: Hs.454528
HGNC ID: HGNC:13487