human VPS26A shRNA silencing AAV

Cat. No: shAAV-227517

Availability: 4-5 weeks

Name: AAV-h-VPS26A-shRNA

This is an AAV expressing shRNA for silencing of Human VPS26A.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: VPS26A
Gene Name: VPS26, retromer complex component A
Gene ID: 9559
Gene Synonyms: HB58; Hbeta58; PEP8A; VPS26
ORF Size: 984 bp
RefSeq#: NM_004896
Gene Description: VPS26A belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniGene ID: Hs.499925
HGNC ID: HGNC:12711