human VDR shRNA silencing AAV

Cat. No: shAAV-227456

Availability: 4-5 weeks

Name: AAV-h-VDR-shRNA

This is an AAV expressing shRNA for silencing of Human VDR.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: VDR
Gene Name: vitamin D (1,25- dihydroxyvitamin D3) receptor
Gene ID: 7421
Gene Synonyms: NR1I1; PPP1R163
ORF Size: 1284 bp
RefSeq#: NM_000376
Gene Description: VDR encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
UniGene ID: Hs.524368
HGNC ID: HGNC:12679