human VDAC3 shRNA silencing AAV

Cat. No: shAAV-227455

Availability: 4-5 weeks

Name: AAV-h-VDAC3-shRNA

This is an AAV expressing shRNA for silencing of Human VDAC3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: VDAC3
Gene Name: voltage dependent anion channel 3
Gene ID: 7419
Gene Synonyms: HD-VDAC3; VDAC-3
ORF Size: 852 bp
RefSeq#: NM_005662
Gene Description: VDAC3 encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene.
UniGene ID: Hs.699301
HGNC ID: HGNC:12674