human VAV1 shRNA silencing AAV

Cat. No: shAAV-227412

Availability: 4-5 weeks

Name: AAV-h-VAV1-shRNA

This is an AAV expressing shRNA for silencing of Human VAV1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: VAV1
Gene Name: vav 1 guanine nucleotide exchange factor
Gene ID: 7409
Gene Synonyms: VAV
ORF Size: 2373 bp
RefSeq#: NM_005428
Gene Description: VAV1 is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniGene ID: Hs.116237
HGNC ID: HGNC:12657