human VAMP2 shRNA silencing AAV

Cat. No: shAAV-227379

Availability: 4-5 weeks

Name: AAV-h-VAMP2-shRNA

This is an AAV expressing shRNA for silencing of Human VAMP2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: VAMP2
Gene Name: vesicle associated membrane protein 2
Gene ID: 6844
Gene Synonyms: SYB2; VAMP-2
ORF Size: 351 bp
RefSeq#: NM_014232
Gene Description: VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
UniGene ID: Hs.25348
HGNC ID: HGNC:12643