human UNC5B shRNA silencing AAV

Cat. No: shAAV-227197

Availability: 6-8 weeks

Name: AAV-h-UNC5B-shRNA

This is an AAV expressing shRNA for silencing of Human UNC5B.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: UNC5B
Gene Name: unc-5 netrin receptor B
Gene ID: 219699
Gene Synonyms: p53RDL1; UNC5H2
ORF Size: 2838 bp
RefSeq#: NM_170744
Gene Description: UNC5B encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.
UniGene ID: Hs.522997
HGNC ID: HGNC:12568