human UNC13B shRNA silencing AAV

Cat. No: shAAV-227183

Availability: 4-5 weeks

Name: AAV-h-UNC13B-shRNA

This is an AAV expressing shRNA for silencing of Human UNC13B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: UNC13B
Gene Name: unc-13 homolog B
Gene ID: 10497
Gene Synonyms: MUNC13; UNC13; Unc13h2
ORF Size: 3594 bp
RefSeq#: NM_006377
Gene Description: UNC13B is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
UniGene ID: Hs.493791
HGNC ID: HGNC:12566