human UBQLN2 shRNA silencing AAV

Cat. No: shAAV-227071

Availability: 4-5 weeks

Name: AAV-h-UBQLN2-shRNA

This is an AAV expressing shRNA for silencing of Human UBQLN2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: UBQLN2
Gene Name: ubiquilin 2
Gene ID: 29978
Gene Synonyms: ALS15; CHAP1; DSK2; HRIHFB2157; N4BP4; PLIC2
ORF Size: 1875 bp
RefSeq#: NM_013444
Gene Description: UBQLN2 encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.
UniGene ID: Hs.179309
HGNC ID: HGNC:12509