human UBE2B shRNA silencing AAV

Cat. No: shAAV-226988

Availability: 4-5 weeks

Name: AAV-h-UBE2B-shRNA

This is an AAV expressing shRNA for silencing of Human UBE2B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: UBE2B
Gene Name: ubiquitin conjugating enzyme E2 B
Gene ID: 7320
Gene Synonyms: E2-17kDa; HHR6B; HR6B; RAD6B; UBC2
ORF Size: 459 bp
RefSeq#: NM_003337
Gene Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
UniGene ID: Hs.644421
HGNC ID: HGNC:12473