human TYR shRNA silencing AAV

Cat. No: shAAV-226938

Availability: 6-8 weeks

Name: AAV-h-TYR-shRNA

This is an AAV expressing shRNA for silencing of Human TYR.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TYR
Gene Name: tyrosinase
Gene ID: 7299
Gene Synonyms: ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
ORF Size: 1134 bp
RefSeq#: NM_000372
Gene Description: The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
UniGene ID: Hs.503555
HGNC ID: HGNC:12442