human TTL shRNA silencing AAV

Cat. No: shAAV-226738

Availability: 4-5 weeks

Name: AAV-h-TTL-shRNA

This is an AAV expressing shRNA for silencing of Human TTL.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TTL
Gene Name: tubulin tyrosine ligase
Gene ID: 150465
ORF Size: 1134 bp
RefSeq#: NM_153712
Gene Description: TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 (PubMed 14571137)).(supplied by OMIM, Mar 2008)
UniGene ID: Hs.358997
HGNC ID: HGNC:21586