human TSC2 shRNA silencing AAV

Cat. No: shAAV-226578

Availability: 4-5 weeks

Name: AAV-h-TSC2-shRNA

This is an AAV expressing shRNA for silencing of Human TSC2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TSC2
Gene Name: tuberous sclerosis 2
Gene ID: 7249
Gene Synonyms: LAM; PPP1R160; TSC4
ORF Size: 5355 bp
RefSeq#: NM_000548
Gene Description: Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniGene ID: Hs.90303
HGNC ID: HGNC:12363