human TRAF3IP2 shRNA silencing AAV

Cat. No: shAAV-226328

Availability: 6-8 weeks

Name: AAV-h-TRAF3IP2-shRNA

This is an AAV expressing shRNA for silencing of Human TRAF3IP2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TRAF3IP2
Gene Name: TRAF3 interacting protein 2
Gene ID: 10758
Gene Synonyms: ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; DKFZp586G0522; MGC3581;
ORF Size: 1698 bp
RefSeq#: NM_001164282
Gene Description: TRAF3IP2 encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. TRAF3IP2 product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
UniGene ID: Hs.654708
HGNC ID: HGNC:1343