human TOP1MT shRNA silencing AAV

Cat. No: shAAV-226201

Availability: 4-5 weeks

Name: AAV-h-TOP1MT-shRNA

This is an AAV expressing shRNA for silencing of Human TOP1MT.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TOP1MT
Gene Name: topoisomerase (DNA) I, mitochondrial
Gene ID: 116447
ORF Size: 1806 bp
RefSeq#: NM_052963
Gene Description: TOP1MT encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniGene ID: Hs.528574
HGNC ID: HGNC:29787