human TNFRSF11A shRNA silencing AAV

Cat. No: shAAV-226071

Availability: 6-8 weeks

Name: AAV-h-TNFRSF11A-shRNA

This is an AAV expressing shRNA for silencing of Human TNFRSF11A.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TNFRSF11A
Gene Name: TNF receptor superfamily member 11a
Gene ID: 8792
Gene Synonyms: CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TRANCER
ORF Size: 1848 bp
RefSeq#: NM_003839
Gene Description: TNFRSF11A is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.
UniGene ID: Hs.204044
HGNC ID: HGNC:11908