human TNF shRNA silencing AAV

Cat. No: shAAV-226055

Availability: 6-8 weeks

Name: AAV-h-TNF-shRNA

This is an AAV expressing shRNA for silencing of Human TNF.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TNF
Gene Name: tumor necrosis factor
Gene ID: 7124
Gene Synonyms: DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F
ORF Size: 702 bp
RefSeq#: NM_000594
Gene Description: TNF encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
UniGene ID: Hs.241570
HGNC ID: HGNC:11892