human TMPRSS2 shRNA silencing AAV

Cat. No: shAAV-226012

Availability: 4-5 weeks

Name: AAV-h-TMPRSS2-shRNA

This is an AAV expressing shRNA for silencing of Human TMPRSS2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TMPRSS2
Gene Name: transmembrane protease, serine 2
Gene ID: 7113
Gene Synonyms: PP9284; PRSS10
ORF Size: 1479 bp
RefSeq#: NM_005656
Gene Description: TMPRSS2 encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. TMPRSS2 was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.439309
HGNC ID: HGNC:11876