human TLN1 shRNA silencing AAV

Cat. No: shAAV-225580

Availability: 4-5 weeks

Name: AAV-h-TLN1-shRNA

This is an AAV expressing shRNA for silencing of Human TLN1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TLN1
Gene Name: talin 1
Gene ID: 7094
Gene Synonyms: ILWEQ; TLN
ORF Size: 7626 bp
RefSeq#: NM_006289
Gene Description: TLN1 encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
UniGene ID: Hs.471014
HGNC ID: HGNC:11845