human TIMP2 shRNA silencing AAV

Cat. No: shAAV-225531

Availability: 4-5 weeks

Name: AAV-h-TIMP2-shRNA

This is an AAV expressing shRNA for silencing of Human TIMP2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TIMP2
Gene Name: TIMP metallopeptidase inhibitor 2
Gene ID: 7077
Gene Synonyms: CSC-21K; DDC8
ORF Size: 663 bp
RefSeq#: NM_003255
Gene Description: TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
UniGene ID: Hs.633514
HGNC ID: HGNC:11821