human TGFB1 shRNA silencing AAV

Cat. No: shAAV-225378

Availability: 4-5 weeks

Name: AAV-h-TGFB1-shRNA

This is an AAV expressing shRNA for silencing of Human TGFB1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TGFB1
Gene Name: transforming growth factor beta 1
Gene ID: 7040
Gene Synonyms: CED; DPD1; LAP; TGFB; TGFbeta
ORF Size: 1173 bp
RefSeq#: NM_000660
Gene Description: TGFB1 encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. TGFB1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
UniGene ID: Hs.645227
HGNC ID: HGNC:11766