human TFPI shRNA silencing AAV

Cat. No: shAAV-225369

Availability: 4-5 weeks

Name: AAV-h-TFPI-shRNA

This is an AAV expressing shRNA for silencing of Human TFPI.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TFPI
Gene Name: tissue factor pathway inhibitor
Gene ID: 7035
Gene Synonyms: EPI; LACI; TFI; TFPI1
ORF Size: 756 bp
RefSeq#: NM_006287
Gene Description: TFPI encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.
UniGene ID: Hs.516578
HGNC ID: HGNC:11760