human TECTA shRNA silencing AAV

Cat. No: shAAV-225292

Availability: 6-8 weeks

Name: AAV-h-TECTA-shRNA

This is an AAV expressing shRNA for silencing of Human TECTA.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TECTA
Gene Name: tectorin alpha
Gene ID: 7007
Gene Synonyms: DFNA12; DFNA8; DFNB21
ORF Size: 6465 bp
RefSeq#: NM_005422
Gene Description: The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.
UniGene ID: Hs.248162
HGNC ID: HGNC:11720