human TCOF1 shRNA silencing AAV

Cat. No: shAAV-225236

Availability: 4-5 weeks

Name: AAV-h-TCOF1-shRNA

This is an AAV expressing shRNA for silencing of Human TCOF1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TCOF1
Gene Name: treacle ribosome biogenesis factor 1
Gene ID: 6949
Gene Synonyms: MFD1; TCS; TCS1; treacle
ORF Size: 2877 bp
RefSeq#: NM_000356
Gene Description: TCOF1 encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.605019
HGNC ID: HGNC:11654