human TCL1A shRNA silencing AAV

Cat. No: shAAV-225227

Availability: 6-8 weeks

Name: AAV-h-TCL1A-shRNA

This is an AAV expressing shRNA for silencing of Human TCL1A.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TCL1A
Gene Name: T-cell leukemia/lymphoma 1A
Gene ID: 8115
Gene Synonyms: TCL1
ORF Size: 345 bp
RefSeq#: NM_021966
Gene Description: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 (PubMed 9520462)). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 (PubMed 10983986)).(supplied by OMIM, Jul 2010)
UniGene ID: Hs.2484
HGNC ID: HGNC:11648