human STAT1 shRNA silencing AAV

Cat. No: shAAV-224536

Availability: Immediate

Name: AAV-h-STAT1-shRNA

This is an AAV expressing shRNA for silencing of Human STAT1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: STAT1
Gene Name: signal transducer and activator of transcription 1
Gene ID: 6772
Gene Synonyms: CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91
ORF Size: 2139 bp
RefSeq#: NM_007315
Gene Description: STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
UniGene ID: Hs.715518
HGNC ID: HGNC:11362