human SSRP1 shRNA silencing AAV

Cat. No: shAAV-224400

Availability: 4-5 weeks

Name: AAV-h-SSRP1-shRNA

This is an AAV expressing shRNA for silencing of Human SSRP1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SSRP1
Gene Name: structure specific recognition protein 1
Gene ID: 6749
Gene Synonyms: FACT; FACT80; T160
ORF Size: 2130 bp
RefSeq#: NM_003146
Gene Description: SSRP1 is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
UniGene ID: Hs.523680
HGNC ID: HGNC:11327