human SRF shRNA silencing AAV

Cat. No: shAAV-224323

Availability: 4-5 weeks

Name: AAV-h-SRF-shRNA

This is an AAV expressing shRNA for silencing of Human SRF.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SRF
Gene Name: serum response factor
Gene ID: 6722
Gene Synonyms: MCM1
ORF Size: 1527 bp
RefSeq#: NM_003131
Gene Description: SRF encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. SRF is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).
UniGene ID: Hs.520140
HGNC ID: HGNC:11291