human SPINT2 shRNA silencing AAV

Cat. No: shAAV-224201

Availability: 4-5 weeks

Name: AAV-h-SPINT2-shRNA

This is an AAV expressing shRNA for silencing of Human SPINT2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SPINT2
Gene Name: serine peptidase inhibitor, Kunitz type 2
Gene ID: 10653
Gene Synonyms: DIAR3; HAI-2; HAI2; Kop; PB
ORF Size: 759 bp
RefSeq#: NM_021102
Gene Description: SPINT2 encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. SPINT2 is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.31439
HGNC ID: HGNC:11247