human SPHK1 shRNA silencing AAV

Cat. No: shAAV-224167

Availability: 4-5 weeks

Name: AAV-h-SPHK1-shRNA

This is an AAV expressing shRNA for silencing of Human SPHK1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SPHK1
Gene Name: sphingosine kinase 1
Gene ID: 8877
Gene Synonyms: SPHK
ORF Size: 1413 bp
RefSeq#: NM_182965
Gene Description: SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.68061
HGNC ID: HGNC:11240