human SORBS2 shRNA silencing AAV

Cat. No: shAAV-223990

Availability: 6-8 weeks

Name: AAV-h-SORBS2-shRNA

This is an AAV expressing shRNA for silencing of Human SORBS2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SORBS2
Gene Name: sorbin and SH3 domain containing 2
Gene ID: 8470
Gene Synonyms: ARGBP2; PRO0618
ORF Size: 1938 bp
RefSeq#: NM_003603
Gene Description: Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniGene ID: Hs.655143
HGNC ID: HGNC:24098