human SOD2 shRNA silencing AAV

Cat. No: shAAV-223982

Availability: 4-5 weeks

Name: AAV-h-SOD2-shRNA

This is an AAV expressing shRNA for silencing of Human SOD2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SOD2
Gene Name: superoxide dismutase 2, mitochondrial
Gene ID: 6648
Gene Synonyms: IPO-B; IPOB; Mn-SOD; MNSOD; MVCD6
ORF Size: 669 bp
RefSeq#: NM_000636
Gene Description: SOD2 is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
UniGene ID: Hs.487046
HGNC ID: HGNC:11180