human SOD1 shRNA silencing AAV

Cat. No: shAAV-223980

Availability: 4-5 weeks

Name: AAV-h-SOD1-shRNA

This is an AAV expressing shRNA for silencing of Human SOD1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SOD1
Gene Name: superoxide dismutase 1, soluble
Gene ID: 6647
Gene Synonyms: ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD
ORF Size: 465 bp
RefSeq#: NM_000454
Gene Description: SOD1 binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
UniGene ID: Hs.443914
HGNC ID: HGNC:11179