human SOCS3 shRNA silencing AAV

Cat. No: shAAV-223975

Availability: 6-8 weeks

Name: AAV-h-SOCS3-shRNA

This is an AAV expressing shRNA for silencing of Human SOCS3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SOCS3
Gene Name: suppressor of cytokine signaling 3
Gene ID: 9021
Gene Synonyms: ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3
ORF Size: 678 bp
RefSeq#: NM_003955
Gene Description: SOCS3 encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
UniGene ID: Hs.527973
HGNC ID: HGNC:19391