human SOCS2 shRNA silencing AAV

Cat. No: shAAV-223974

Availability: 4-5 weeks

Name: AAV-h-SOCS2-shRNA

This is an AAV expressing shRNA for silencing of Human SOCS2.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SOCS2
Gene Name: suppressor of cytokine signaling 2
Gene ID: 8835
Gene Synonyms: CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
ORF Size: 597 bp
RefSeq#: NM_003877
Gene Description: SOCS2 encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. SOCS2 has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
UniGene ID: Hs.485572
HGNC ID: HGNC:19382