human SMOX shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-223766
Availability:
6-8 weeks
Name:
AAV-h-SMOX-shRNA
This is an AAV expressing shRNA for silencing of Human SMOX.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- SMOX
- Gene Name
- spermine oxidase
- Gene ID
- 54498
- Gene Synonyms
- C20orf16; PAO; PAO-1; PAO1; PAOH; PAOH1; SMO
- ORF Size
- 1509 bp
- RefSeq#
- NM_175842
- Gene Description
- Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.
- UniGene ID
- Hs.433337
- HGNC ID
- HGNC:15862
Related Products
Product | Cat No. |
---|---|
AAV-h-SMOX | AAV-223766 |
AAV-m-SMOX | AAV-272656 |
Ad-h-SMOX | ADV-223766 |
Ad-m-SMOX | ADV-272656 |
AAV-m-SMOX-shRNA | shAAV-272656 |
Ad-h-SMOX-shRNA | shADV-223766 |
Ad-m-SMOX-shRNA | shADV-272656 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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