human SMG7 shRNA silencing AAV

Cat. No: shAAV-223755

Availability: 4-5 weeks

Name: AAV-h-SMG7-shRNA

This is an AAV expressing shRNA for silencing of Human SMG7.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SMG7
Gene Name: SMG7, nonsense mediated mRNA decay factor
Gene ID: 9887
Gene Synonyms: C1orf16; EST1C; SGA56M
ORF Size: 3537 bp
RefSeq#: NM_173156
Gene Description: SMG7 encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
UniGene ID: Hs.591463
HGNC ID: HGNC:16792