human SMAD4 shRNA silencing AAV

Cat. No: shAAV-223692

Availability: 4-5 weeks

Name: AAV-h-SMAD4-shRNA

This is an AAV expressing shRNA for silencing of Human SMAD4.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SMAD4
Gene Name: SMAD family member 4
Gene ID: 4089
Gene Synonyms: DPC4; JIP; MADH4; MYHRS
ORF Size: 1659 bp
RefSeq#: NM_005359
Gene Description: SMAD4 encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
UniGene ID: Hs.75862
HGNC ID: HGNC:6770