human SIRT2 shRNA silencing AAV

Cat. No: shAAV-223015

Availability: 4-5 weeks

Name: AAV-h-SIRT2-shRNA

This is an AAV expressing shRNA for silencing of Human SIRT2.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SIRT2
Gene Name: sirtuin 2
Gene ID: 22933
Gene Synonyms: SIR2; SIR2L; SIR2L2
ORF Size: 1059 bp
RefSeq#: NM_012237
Gene Description: SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
UniGene ID: Hs.466693
HGNC ID: HGNC:10886