human SIAH1 shRNA silencing AAV

Cat. No: shAAV-222980

Availability: 4-5 weeks

Name: AAV-h-SIAH1-shRNA

This is an AAV expressing shRNA for silencing of Human SIAH1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SIAH1
Gene Name: siah E3 ubiquitin protein ligase 1
Gene ID: 6477
Gene Synonyms: SIAH1A
ORF Size: 942 bp
RefSeq#: NM_003031
Gene Description: SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
UniGene ID: Hs.295923
HGNC ID: HGNC:10857