human SHPK shRNA silencing AAV

Cat. No: shAAV-222960

Availability: 4-5 weeks

Name: AAV-h-SHPK-shRNA

This is an AAV expressing shRNA for silencing of Human SHPK.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SHPK
Gene Name: sedoheptulokinase
Gene ID: 23729
Gene Synonyms: CARKL; SHK
ORF Size: 1437 bp
RefSeq#: NM_013276
Gene Description: SHPK has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements.
UniGene ID: Hs.579217
HGNC ID: HGNC:1492