human SHMT1 shRNA silencing AAV

Cat. No: shAAV-222952

Availability: 4-5 weeks

Name: AAV-h-SHMT1-shRNA

This is an AAV expressing shRNA for silencing of Human SHMT1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SHMT1
Gene Name: serine hydroxymethyltransferase 1
Gene ID: 6470
Gene Synonyms: CSHMT; SHMT
ORF Size: 1452 bp
RefSeq#: NM_004169
Gene Description: SHMT1 encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. SHMT1 is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
UniGene ID: Hs.636044
HGNC ID: HGNC:10850