human SFRS2 shRNA silencing AAV

Cat. No: shAAV-222800

Availability: 4-5 weeks

Name: AAV-h-SFRS2-shRNA

This is an AAV expressing shRNA for silencing of Human SRSF2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SRSF2
Gene Name: serine and arginine rich splicing factor 2
Gene ID: 6427
Gene Synonyms: PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b
ORF Size: 666 bp
RefSeq#: NM_003016
Gene Description: SRSF2 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.
UniGene ID: Hs.713672
HGNC ID: HGNC:10783