human SFRP1 shRNA silencing AAV

Cat. No: shAAV-222780

Availability: 4-5 weeks

Name: AAV-h-SFRP1-shRNA

This is an AAV expressing shRNA for silencing of Human SFRP1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SFRP1
Gene Name: secreted frizzled related protein 1
Gene ID: 6422
Gene Synonyms: FRP; FRP-1; FRP1; FrzA; SARP2
ORF Size: 945 bp
RefSeq#: NM_003012
Gene Description: SFRP1 encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. SFRP1 may also be involved in determining the polarity of photoreceptor cells in the retina.
UniGene ID: Hs.713546
HGNC ID: HGNC:10776