human SF3B2 shRNA silencing AAV

Cat. No: shAAV-222762

Availability: 4-5 weeks

Name: AAV-h-SF3B2-shRNA

This is an AAV expressing shRNA for silencing of Human SF3B2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SF3B2
Gene Name: splicing factor 3b subunit 2
Gene ID: 10992
Gene Synonyms: Cus1; SAP145; SF3b1; SF3B145; SF3b150
ORF Size: 1911 bp
RefSeq#: NM_006842
Gene Description: SF3B2 encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.
UniGene ID: Hs.406423
HGNC ID: HGNC:10769