human SEC61B shRNA silencing AAV

Cat. No: shAAV-222504

Availability: 4-5 weeks

Name: AAV-h-SEC61B-shRNA

This is an AAV expressing shRNA for silencing of Human SEC61B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SEC61B
Gene Name: Sec61 translocon beta subunit
Gene ID: 10952
ORF Size: 291 bp
RefSeq#: NM_006808
Gene Description: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.
UniGene ID: Hs.191887
HGNC ID: HGNC:16993